How Simvastatin Works





Simvastatin is a medication referred to the class of statins. Simvastatin lowers “bad” cholesterol levels in the blood by reducing the production of LDL cholesterol in the liver, which is achieved by suppressing the action of HMG-CoA reductase in the liver, an enzyme responsible for the production of cholesterol. The decreased amounts of LDL cholesterol in the liver makes liver cells compensate the imbalance by taking cholesterol from the blood stream. As a result, the levels of LDL cholesterol in the blood decrease. It is important to note that simvastatin is the most effective when taken at or before  night because most cholesterols  are produced in the body at night.

What is “bad” cholesterol or LDL?

LDL stands for low density lipoprotein, the type of cholesterol that accumulates in the arteries and narrows them (atherosclerosis) which is associated with high risks of heart disease. As opposed to LDL, the so called “good” cholesterol (HDL, high density lipoprotein) prevents depositing “bad” cholesterol in the arteries.

Narrowed or blocked arteries limit the amount of oxygen delivered to the heart muscle, which results in chest pain (angina) and in worst cases - a heart attack (myocardial infarction).  Timely treatment with simvastatin can prevent first or second heart attack, which is the major benefit of the medication that outweighs the risk of the side effects of simvastatin.  That is why it is so important to know your LDL levels, especially if your lifestyle is not quite healthy, and contact a doctor in case  of such warning signs as chest pain.

A small decrease in the production of triglycerides (other ‘bad fats’ ) in the blood called and a slight increase of “good”  cholesterol is  an additional beneficial effect of Simvastatin.