What Is Generic Simvastatin?




A generic is the medication sold without a brand name. That is why the term “generic name for simvastatin” or “generic simvastatin” is not quite correct: simvastatin is the generic name for the medication. Brand simvastatin and generic simvastatin are nearly identical. Specifically, they have the same dosage form, intended use, route of administration, strength, quality and performance characteristics and, most important, the same active ingredients. Medical professionals tend to use generic names in prescriptions. Primarily, simvastatin was patented under the brand name Zocor by Merck & Co . In 2006 the patent expired which granted other drug manufacturers to produce the medication with the same active component, simvastatin. Specifically, they have the same active component, the one that actually treats your body. But compared to branded simvastatin, generic simvastatin costs considerably less. Simvastatin is also available in the following strengths: 5 milligram tablets, 10 milligram tablets, 20 milligram tablets, 40 milligram tablets, and 80 milligram tablets. One of the most common concerns about simvastatin is its price. That’s why many patients opt for generic simvastatin. But what’s the difference between the brand and generic simvastatin? The simvastatin generic price range of about 90-320 tablets starts around $20-$85. Currently brand simvastatin is sold under the names Zocor (USA), Simcard, Simlup, Simvotin (India), Denan (Germany), Simvahexal (Australia), Simvastatin-Teva, Simvacor, Simvaxon, Simovil (Israel).

Is It Safe to Use Generic Simvastatin?

Yes, as long as generic simvastatin tablets are produced by reputable manufacturers and are FDA-approved.

Generic Simvastatin: History

Simvastatin generics are lipid lowering agents that reduce the serum cholesterol levels of a person through their inhibitory action on HMG-CoA reductase. Blood levels of LDLs, or low density lipoproteins, and blood levels of VLDLs, or very low density lipoproteins, significantly decrease after ingestion of the drug, in accordance with a steady therapeutic regimen. It is because simvastatin acts by speeding up the catabolism, or chemical breakdown, of low density lipoproteins and very low density lipoproteins. As a direct result, the consumer of simvastatin generics would have markedly lower chances of incurring cardiovascular diseases when following a treatment program that includes the drug. In 1959, an enzyme that contributes to cholesterol synthesis in the human body known as 3-hydroxy-3-methyl-glutaryl-CoA reductase enzyme, or the HMG-CoA reductase enzyme, was identified and isolated by the researchers at a certain institute. This was a huge breakthrough in the field of science, as it marked the newfound possibility of creating new treatment regimens for individuals with cholesterol problems. In 1976, a scientist named Akira Endo was able to isolate the first cholesterol inhibitor known as Compactin, ML-236B from the fungus Penicillium citrinium. But by 1979, another scientist named Hoffman, along with his colleagues, had isolated lovastatin from an Aspergillus fungus, the first commercial HMG-CoA inhibitor. But some scientists were not contented; after fermenting the product of an Aspergillus terreus sample, they have made a more potent inhibitor: generic simvastatin.

Generic Simvastatin Warning

Although generic simvastatin is favored for its anti-lipid effect, it also comes with other bad effects. Simvastatin generics are extremely not recommended in patients with active liver disease and those with elevated transaminase levels. This claim is supported by the fact that simvastatin generics are hepatotoxic, or liver-damaging. In addition to this, patients who have a history of other liver diseases or alcohol abuse are contraindicated to this drug therapy. Generic simvastatin should not also be taken with other lipid-lowering agents, as it may predispose the user to rhabdomyolysis. Simvastatin generics also cause certain side effects such as those which involve the central nervous system. Simvastatin side effects include the common signs and symptoms of insomnia and paresthesias, or tingling of the hands and feet. For other clients taking this drug, simvastatin may also cause signs and symptoms related to the cardiovascular system like chest pains, or angina pectoris. Concerning dermal side effects, some consumers may get bald during the course of the treatment with simvastatin. For gastrointestinal signs and symptoms, consumers are predisposed to elevated transaminase levels, acid resurge, dry mouth, and occasional vomiting. For the musculoskeletal system, clients may also experience: myalgia, or muscle pain; myopathy, or muscle deformation, and; rhabdomyolysis, or muscle degeneration.