Simvastatin Drug Interactions

As any other medicine, simvastatin may interact with other drugs, food supplements or foods.  As a result of drug interactions, the medicines may be metabolized differently than intended which may increase the risk of developing simvastatin side effects. At least 149 different medicines (a total of 480 brand and generic names) may interact with simvastatin, 41 of interactions are major, 99 are moderate and 9 are minor.

Simvastatin InteractionsThat is why it is important to inform your healthcare provider about all the medications, food supplements (including vitamins, minerals, herbal products ) you take before starting treatment with simvastatin. Do not start taking new drugs while on simvastatin without telling your doctor.

Many drugs can interact with simvastatin, below is just a list of the most common simvastatin interactions:

  • HIV or AIDS medication such as saquinavir (Invirase, Fortovase), ritonavir (Norvir), amprenavir (Agenerase), indinavir (Crixivan), lopinavir-ritonavir (Kaletra), or nelfinavir (Viracept)
  • antifungal medications such as fluconazole (Diflucan), itraconazole (Sporanox) or ketoconazole (Nizoral);
  • drugs that suppress your immune system such as cancer medicines, some rheumatoid arthritis drugs or steroids, cyclosporine (Neoral, Sandimmune, Gengraf), leflunomide (Arava), tacrolimus (Prograf), Cyclophosphamide, sirolimus (Rapamune), and others;
  • diltiazem (Cartia, Tiazac, Dilacor, Cardizem), amiodarone (Cordarone), or verapamil (Verelan, Isoptin, Calan);
  • colestipol (Colestid) or cholestyramine (Questran)
  • warfarin (Coumadin);
  • clofibrate (Atromid-S), fenofibrate (Tricor) or gemfibrozil (Lopid)
  • nefazodone (Serzone);
  • clarithromycin (Biaxin), erythromycin (Ery-Tab, E-Mycin, others), or telithromycin (Ketek);
  • danazol (Danocrine);
  • niacin (Slo-Niacin, Nicobid, Nicolar, others);

Attention! Taking simvastatin with grapefruit, grapefruit juice, or grapefruit supplements can increase the level of simvastatin in your blood.